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CYP3A4 inducers might improve the development from the neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde. Intently monitor sufferers getting ifosfamide with CYP3A4 inducers for toxicities and consider dose adjustment.pentobarbital will lessen the extent or influence of tipranavir by influencing hepatic/intestinal enzyme CYP3A4 metabo